WEEKLY READINGS AND RESOURCES

Additional Material will be Distributed During Class and via Courseworks

Lecture 1: Responsible Conduct of Research: What Is It?

Assigned text: Macrina, F.L. Scientific Integrity. Chapters 1. and 2.
CU Office of Research Compliance and Training: Research Misconduct
CU Institutional Policy on Misconduct in Research
Couzin J. Scientific misconduct. Truth and consequences. Science. 2006 Sep;313(5791):1222-6. Erratum in: Science. 2007 Feb 9;315(5813):766.
Additional material distributed in class and via CourseWorks.

Lecture 2: Mentorship

Dr. Arthur Palmer's Slide Presentation
Dr. Arthur Palmer's Case Studies
Assigned text: Macrina, F.L. Scientific Integrity. Chapter 3.
AAMC's Compact Between Postdoctoral Appointees and Their Mentors
AAMC's Compact Between Biomedical Graduate Students and Their Research Advisors
Hill, Linda. Becoming a Manager: How New Managers Master the Challenges of Leadership, 2nd ed. Harvard Business Review Press, 2003. ISBN-13: 978-1591391821.
CU's Graduate School of Arts and Sciences' Policies and Resources

Lecture 3: Humane and Responsible Use of Laboratory
Animals in Scientific Research

Assigned text: Macrina, F.L. Scientific Integrity. Chapter 6.
CU Institute of Comparative Medicine
CU Institutional Animal Care And Use Committee
Columbia University: Animal Research Handbook
Regulatory and Guidance Documents:
Guide for the Care & Use of Laboratory Animals, 8th edition
Office of Laboratory Animal Welfare, the including Public Health Service Policy on Humane Care & Use of Laboratory Animals

Lecture 4: Science at a Crossroads: Time for Reform?

Assigned text: Macrina, F.L. Scientific Integrity. Chapter 11.
Broderick, NA, Casadevall, A. Disequilibrium in Gender Ratios among Authors who Contributed Equally. https://www.biorxiv.org/content/early/2017/12/31/241554. posted December 31, 2017.

Lectures 5 and 7: Research with Human Subjects/Participants

Dr. Neil Schluger's Slide Presentation
Dr. Elaine Larson's Slide Presentation
Assigned text: Macrina, F.L. Scientific Integrity. Chapter 5.
CUMC Institutional Review Board and Human Research Protection Program, including links to ethical principles, government regulations, and policies and guidances
The Belmont Report - Ethical Principles and Guidelines for the Protection of Human Subjects of Research (National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research).

Lecture 6: Authorship, Publications, and Peer Review

Assigned text: Macrina, F.L. Scientific Integrity. Chapter 4.

Lecture 8: Data Management and Sharing/Reproducubility

Assigned text: Macrina, F.L. Scientific Integrity. Chapters 9. and 11

Lecture 9: Research with Industry Partners/Intellectual Property/
Technology Transfer/Conflict of Interest

Assigned text: Macrina, F.L. Scientific Integrity. Chapters 7., 8., and 9.
Columbia University Policies and Resources
Stevens AJ. The enactment of Bayh-Dole. Journal of Technology Transfer. 2004. 29(1), 93-99. Full text of article
Stolberg SG. Financial ties in biomedicine get close look. NY Times. Feb 20, 2000. Full text of article
Gillis J and Schwartz J. Deeper ties to corporate cash for doubtful climate researcher. NY Times. Feb 21, 2015. Full text of article
Gillis J. Climate change researcher offers a defense of his practices. NY Times. Mar 2, 2015. Full text of article

Lecture 11: Strategies for a Successful Research Career

Landry DW, Zucker HA. Embryonic death and the creation of human embryonic stem cells. J Clin Invest. 2004 Nov;114(9):1184-6. Full text of article
Landry DW, Oliver JA. Insights into shock. Sci Am. 2004 Feb;290(2):36-41.
Landry DW, Oliver JA. The pathogenesis of vasodilatory shock. N Engl J Med. 2001 Aug 23;345(8):588-95. Full text of article
Landry DW. Immunotherapy for cocaine addiction. Sci Am. 1997 Feb;276(2):42-5.
Landry DW, Levin HR, Gallant EM, Ashton RC Jr, Seo S, D'Alessandro D, Oz MC, Oliver JA. Vasopressin deficiency contributes to the vasodilation of septic shock. Circulation. 1997 Mar 4;95(5):1122-5. Full text of article
Landry DW, Zhao K, Yang GX, Glickman M, Georgiadis TM. Antibody-catalyzed degradation of cocaine. Science. 1993 Mar 26;259(5103):1899-901. Full text of article