WEEKLY READINGS AND RESOURCES

Lecture 1: Mentorship

Dr. Arthur Palmer's Slide Presentation
Dr. Arthur Palmer's Case Studies
Assigned text: Macrina, F.L. Scientific Integrity. Chapter 3.
AAMC's Compact Between Postdoctoral Appointees and Their Mentors
AAMC's Compact Between Biomedical Graduate Students and Their Research Advisors
CU's Graduate School of Arts and Sciences' Grievance Policy

Lecture 2: Conflict of Interest, Intellectual Property, and Collaborative Research

Assigned text: Macrina, F.L. Scientific Integrity. Chapters 7., 8., and 9.
Columbia University Policies and Resources
Stevens AJ. The enactment of Bayh-Dole. Journal of Technology Transfer. 2004. 29(1), 93-99. Full text of article
Stolberg SG. Financial ties in biomedicine get close look. NY Times. Feb 20, 2000. Full text of article
Gillis J and Schwartz J. Deeper ties to corporate cash for doubtful climate researcher. NY Times. Feb 21, 2015. Full text of article
Gillis J. Climate change researcher offers a defense of his practices. NY Times. Mar 2, 2015. Full text of article

Lecture 3: Responsible Conduct of Research: What Is It?

Assigned text: Macrina, F.L. Scientific Integrity. Chapters 1. and 2.
CU Institutional Policy on Misconduct in Research
Couzin J. Scientific misconduct. Truth and consequences. Science. 2006 Sep;313(5791):1222-6. Erratum in: Science. 2007 Feb 9;315(5813):766.
Additional material distributed in class and via CourseWorks.

Lecture 4: Science at a Crossroads: Time for Reform?

Assigned text: Macrina, F.L. Scientific Integrity. Chapter 11.
Fang FC, Casadevall A. Diseased science. Microbe. 2014. Vol. 9. No. 10. pp. 1-3. Full text of article
Stern AM, Casadevall A, Steen RG, Fang FC. Financial costs and personal consequences of research misconduct resulting in retracted publications. Elife. 2014 Aug 14;3:e02956 Full text of article
Fang FC, Steen RG, Casadevall A. Misconduct accounts for the majority of retracted scientific publications. Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):17028-33. Full text of article
Fang FC, Bennett JW, Casadevall A. Males are overrepresented among life science researchers committing scientific misconduct. MBio. 2013 Jan 22;4(1):e00640-12. Full text of article
Fang FC, Casadevall A. Why we cheat. Sci Amer Mind. 2013 May/June. Vol 24. Issue 2. pp. 33-39. Full text of article

Lectures 5 and 6: Research with Human Subjects/Participants

Dr. Neil Schluger's Slide Presentation
Dr. Elaine Larson's Slide Presentation
Assigned text: Macrina, F.L. Scientific Integrity. Chapter 5.
CUMC Institutional Review Board and Human Research Protection Program, including links to ethical principles, government regulations, and policies and guidances

Lecture 7: Issues in Genetics Research/Precision Medicine

Assigned text: Macrina, F.L. Scientific Integrity. Chapter 11.

Lecture 8: Authorship, Publications, and Peer Review

Assigned text: Macrina, F.L. Scientific Integrity. Chapter 4.

Lecture 9: Humane and Responsible Use of Laboratory
Animals in Scientific Research

Assigned text: Macrina, F.L. Scientific Integrity. Chapter 6.
Dr. Brian Karolewski's Slide Presentation
CU Medical Research Involving Animals
Practical Guide: Columbia University Animal Research Handbook
Regulatory and Guidance Documents:
Guide for the Care & Use of Laboratory Animals, 8th edition
The Animal Welfare Act & Animal Welfare Regulations
Office of Laboratory Animal Welfare, the including Public Health Service Policy on Humane Care & Use of Laboratory Animals

Lecture 10: Data Management and Sharing/Reproducubility

Assigned text: Macrina, F.L. Scientific Integrity. Chapters 9. and 11
Dr. Richard Kessin's Slide Presentation

Lecture 11: Strategies for a Successful Research Career

Landry DW, Zucker HA. Embryonic death and the creation of human embryonic stem cells. J Clin Invest. 2004 Nov;114(9):1184-6. Full text of article
Landry DW, Oliver JA. Insights into shock. Sci Am. 2004 Feb;290(2):36-41.
Landry DW, Oliver JA. The pathogenesis of vasodilatory shock. N Engl J Med. 2001 Aug 23;345(8):588-95. Full text of article
Landry DW. Immunotherapy for cocaine addiction. Sci Am. 1997 Feb;276(2):42-5.
Landry DW, Levin HR, Gallant EM, Ashton RC Jr, Seo S, D'Alessandro D, Oz MC, Oliver JA. Vasopressin deficiency contributes to the vasodilation of septic shock. Circulation. 1997 Mar 4;95(5):1122-5. Full text of article
Landry DW, Zhao K, Yang GX, Glickman M, Georgiadis TM. Antibody-catalyzed degradation of cocaine. Science. 1993 Mar 26;259(5103):1899-901. Full text of article